We are pleased to announce that our Dr. Panoskaltsis’ work on TGN1412-induced cytokine storm has been published in Cancer Immunology, Immunotherapy. The article entitled “Myelopoiesis of acute inflammation: lessons from TGN1412-induced cytokine storm” highlights TGN1412, a superagonist monoclonal antibody targeting CD28, which caused cytokine storm in six healthy volunteers in a first-in-man study in 2006. The TGN1412-induced cytokine storm offers unique insights into the pathogenesis of anemia of inflammation and offer immunological correlates and insights into the hematopoiesis of inflammation, aging, and BM failure disorders such as MDS..
Dr. Mantalaris was recently interviewed by Genetic Engineering and Biotechnology News. Check out there story on BSEL’s predictive model of cell cycle, metabolism, and apoptosis of monoclonal antibody producing cells and the delicate balance behind bioprocess modeling. Read more here